The first two days of the course will introduce and detail basic and intermediate biomaterials, cell biology, and reactor engineering concepts that are essential for professionals participating in, or evaluating, the development and production of tissue engineering constructs. The first day will emphasize the materials, properties, and assays that are used for engineering materials for human use. The second day will detail the microbiology, reactor engineering, and macroscopic cell responses necessary to immediately grow cells on these materials.
Throughout the course, participants are encouraged to ask questions and discuss examples relevant to their own work. The following include a few of the topic areas to be discussed:
- Introduction, and skin engineering examples
- Biomaterials – Polymers, Collagens, Silks
- Scaffolds – matrices, electrospinning, dip pen lithography
- Characterization – bulk and surface properties
- Exercise 1 – Synthetic Ligament Replacement
- Stem cells – Sources, growth promoters, physical differentiation cues
- Bioreactors – oxygenation, nutrients, physical stimulus
- Cellular responses to biomaterials – clotting, adhesion, migration, immune response
- Evaluations – Toxicology, Histology, in vivo testing
- Exercise 2 – Spinal Fusion Implants
On day three, the concepts from prior days will be integrated using group projects to practice the application of evaluating and developing plans to market tissue engineering and regenerative medicine products.
Who Should Attend
This training course is designed as an introduction to the principles of Tissue Engineering and Regenerative Medicine. Topics included will benefit individuals within the pharmaceutical, biotech and device industries including medical investigators, basic and clinical research scientists, clinical research associates, and those involved in regulatory affairs. Additionally, personnel not directly involved with tissue engineering who need to understand regulatory and technical aspects of this activity will find this course highly beneficial.
The course will concentrate on biology and engineering concepts related to the materials, cells, and bioreactors that are necessary to build successful tissues. These concepts will be presented through the use of many case studies of actual tissue engineering successes. Through this application approach, the material in the lectures is accessible both to those with experience in tissue engineering and professionals having little or no formal training in engineering or biology.
The course provides a thorough understanding of the activities involved during Phase 3 and 4 of Drug Development. Those completing this course will have an understanding of the engineering assembly of cells, growth promoters, scaffolds, and reactors essential to tissue engineering research. Participants will be able to evaluate data and research plans, as well as, review scientific literature related to tissue engineering applications.